Page 1 of 1

Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Tue Oct 07, 2014 7:40 pm
by josh
Hi All,

In dealing with a new bleed, I am faced with the same "now what" that we all have. The problem is the damage left over from the bleed on the local brain tissue, and an important issue long discussed around here is the issue of the remaining hemosiderin deposits from the blood breakdown, which create their own long term issues in brain function, and possible "glial cell" death.

So quick question, anyone try anti-hemosiderin (iron chelator) therapy with something like Deferiprone ?

When researching ways to help clear hemosiderin deposits, I came upon Deferiprone as a candidate. A couple papers below...

--Josh

=====
Here is a paper from 2010 that discusses this use:

http://www.ajnr.org/content/32/1/E1.full

Deferiprone Reduces Hemosiderin Deposits in the Brain of a Patient with Superficial Siderosis
"While the exact mechanism is unknown, the amount and location of hemosiderin deposition on MR imaging correlate with symptoms and disease burden, with most patients presenting with a combination of hearing loss, cerebellar ataxia, and/or myelopathy due to involvement of the vestibular nerve (eighth cranial nerve), cerebellum, and spinal cord.2"

"We report on a patient with superficial siderosis who was treated with deferiprone for 1.5 years. We found a remarkable reduction in hemosiderin on MR imaging of the brain, associated with clinical improvement in symptoms."

"The presumed mechanism of disease in superficial siderosis is toxicity from iron breakdown products causing glial cell death and eventual neurodegeneration."
=====

Here is a broader study of the same drug from 2011:

"Pilot Safety Trial of Deferiprone in 10 Subjects With Superficial Siderosis"
http://stroke.ahajournals.org/content/43/1/120.full.pdf

"The mechanism of disease involves overwhelming toxic iron sequestering by glial cells, and the amount and location of hemosiderin deposition on MR imaging correlate with symptoms and disease burden."

"Recently, we demonstrated the safety and therapeutic efficacy of using deferiprone (L1), a lipid-soluble iron chelator that can cross the blood–brain barrier. This was the first proof-of-concept case showing that removing the iron could stabilize or reverse the disease process"

"Although the time between the last pretrial MRI and the post-trial MRI varied in this ad-hoc
analysis, we still found that a 90-day course of deferiprone therapy was associated with a decrease in hemosiderin deposition by MRI in 4 of the 9 subjects."

"4 subjects claimed to have subjective improvement in neurological function ranging from better coordina-
tion and gait to better hearing, more energy, clearer thinking, and reduced spasticity"

Re: Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Tue Oct 07, 2014 8:28 pm
by vandy
Very interesting. I will have to study up on this !

Henk :ugeek:

Re: Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Sun Oct 12, 2014 10:11 am
by kirkmc
Some years ago, I asked my neurologist about chelation drugs; they're commonly used when there are build-ups of hemosiderin in various organs, but he told me that none of them crossed the brain/blood barrier. These drugs seem to be newer, so i, for one, would be very interested in knowing if they do work, and what the side effects may be. I have a lot of hemosiderin around my lesion, and if some of it could be removed, it could be helpful.

Perhaps one of the science people can weigh in; I'll let them know about this thread.

Kirk

Re: Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Mon Jan 12, 2015 11:51 pm
by josh
FYI, the neuros that I spoke with about this thought this was pretty far out from what they would consider doing. One top doc suggested better to focus on vascular stabilization as the pressing concern rather than dealing with hemosiderin remnants.

Re: Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Wed Jan 14, 2015 1:37 am
by josh
Just saw this posted on Facebook when someone asked about this there...

"Connie Sarwatka Lee - I talked with Dr. Awad about this medication at our scientific meeting. I had already noticed that the side effect profile for the medication is scary, but I wanted to check in with him. Dr. Awad didn't feel it would be appropriate for people with cavernous angiomas. The drug is intended for large deposits of blood/iron like you would have with TBI or an AVM rupture, not for the small deposits that result from cavernous angioma bleeding/leakage. That doesn't mean there won't someday be a version of this medication appropriate for cavernous angioma - this just isn't it yet."

Re: Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Sun Oct 21, 2018 8:19 pm
by gardengirl1975
Having had completely useless neurologists, I've had to do research on my own. I found Serrapeptase, and did a whole lot of research on it - it breaks down non living tissue, reduces inflammation, reduces scar tissue, helps with pain (a bit). It's what they use in Europe after surgery instead of nsaid's and opiats. I've been taking it for maybe 3 yrs, and the number of stroke/tia's have gone down and I can think clearer. I DID find a scientific abstract about serrapeptase reducing hemosiderin deposits in the brain - I'd have to relook if anyone wants me to post it. It has NO side effects for me. As a bonus, it also shrinks up the cyst in my left breast, and the giant intramuscular hemangioma under my left butt cheek that makes it feel like I'm sitting on a rock. I'm trying to get discs of my previous mri's so I can try to see any changes for myself, to see if the serrapeptase is having any measurable effect.

Re: Hemosiderin Treatment/Removal with Deferiprone

PostPosted: Thu Dec 20, 2018 4:48 pm
by Connie Lee
I'm not familiar with Serrapeptase, but a quick internet search cautioned that it falls into the category of blood thinner - have any doctors commented on this vis a vis your cavernous angioma?